One-Pot, Three-Component Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Starting from Primary Alcohols

被引：22
|
作者：
Jin, Guanyi [1 ]
Zhang, Jian [1 ]
Fu, Dan [1 ]
Wu, Jingjing [1 ]
Cao, Song [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 28期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Multicomponent reactions; Nitrogen heterocycles; Alcohols; Ketones; RUTHENIUM-CATALYZED CYCLOADDITION; AZIDE-ALKYNE CYCLOADDITION; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; CLICK CHEMISTRY; DIRECT ARYLATION; ORGANIC AZIDES; TRIAZOLE; DESIGN;
D O I：
10.1002/ejoc.201200830
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, one-pot, three-component approach for the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles through the cycloaddition of a wide range of primary alcohols with sodium azide and active methylene ketones in the presence of N-(p-toluenesulfonyl)imidazole, tetrabutylammonium iodide, and triethylamine in DMF/DMSO has been developed.
引用
收藏
页码：5446 / 5449
页数：4
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