ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490I.: Taxonomy, fermentation, isolation and biological activities

被引：4
|
作者：
Inoue, H
Kumagai, H
Osono, M
Matsufuji, M
Sameshima, T
Kawamura, N
Someno, T
Ishizuka, M
Takeuchi, T
机构：
[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan
[2] Mercian Co Ltd, Bioresource Res Labs, Fujisawa, Kanagawa 2510057, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期
关键词：
D O I：
10.7164/antibiotics.56.209
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 mug/ml and showed weak cytotoxicity against bone marrow cells.
引用
收藏
页码：209 / 213
页数：5
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