ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490 -: II.: Structure determination and synthesis

被引：4
|
作者：
Someno, T [1 ]
Inoue, H [1 ]
Kumagai, H [1 ]
Ishizuka, M [1 ]
Takeuchi, T [1 ]
机构：
[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期
关键词：
D O I：
10.7164/antibiotics.56.214
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
ICM0201 (1), a new inhibitor of murine osteoclastogenesis in culture was isolated from a fermentation broth of Cunninghamella sp. F-1490. The structure of ICM0201 was determined to be (3S,10aR)-3,4a-dihydroxy-2,3,4,4a-tetrahydro-2H-pyrano[3,2-b]benzo[e]morpholine-9-carboxylic acid by spectroscopic analyses and chemical studies. The structure of I is unique in that the tricycle ring system is composed of aminal and hemiacetal bonds.
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收藏
页码：214 / 218
页数：5
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