ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490 -: II.: Structure determination and synthesis

被引：4

作者：

Someno, T ^{[1
]}

Inoue, H ^{[1
]}

Kumagai, H ^{[1
]}

Ishizuka, M ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期

关键词：

D O I：

10.7164/antibiotics.56.214

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

ICM0201 (1), a new inhibitor of murine osteoclastogenesis in culture was isolated from a fermentation broth of Cunninghamella sp. F-1490. The structure of ICM0201 was determined to be (3S,10aR)-3,4a-dihydroxy-2,3,4,4a-tetrahydro-2H-pyrano[3,2-b]benzo[e]morpholine-9-carboxylic acid by spectroscopic analyses and chemical studies. The structure of I is unique in that the tricycle ring system is composed of aminal and hemiacetal bonds.

引用

页码：214 / 218

页数：5

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