MS-681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp.: II.: Physico-chemical properties and structure elucidation

被引：7
|
作者：
Ikuina, Y [1 ]
Bando, C [1 ]
Yoshida, M [1 ]
Yano, H [1 ]
Saitoh, Y [1 ]
机构：
[1] Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Tokyo 194, Japan
来源：
JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 12期
关键词：
D O I：
10.7164/antibiotics.50.998
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MS-681a, b, c and d are new inhibitors of myosin light chain kinase produced by Myrothecium sp. They are novel octapeptides containing alpha-alkyl-alpha-amino acids and a polyamine moiety. The structures were determined by NMR and FAB-MS/MS spectral analyses of the intact peptides. Their absolute configurations were elucidated by GC analysis on a chiral column of the constituent amino acids and by chemical synthesis of the polyamine moieties.
引用
收藏
页码：998 / 1006
页数：9
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