MS-681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp.: II.: Physico-chemical properties and structure elucidation

被引：7

作者：

Ikuina, Y ^{[1
]}

Bando, C ^{[1
]}

Yoshida, M ^{[1
]}

Yano, H ^{[1
]}

Saitoh, Y ^{[1
]}

机构：

[1] Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Tokyo 194, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 12期

关键词：

D O I：

10.7164/antibiotics.50.998

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MS-681a, b, c and d are new inhibitors of myosin light chain kinase produced by Myrothecium sp. They are novel octapeptides containing alpha-alkyl-alpha-amino acids and a polyamine moiety. The structures were determined by NMR and FAB-MS/MS spectral analyses of the intact peptides. Their absolute configurations were elucidated by GC analysis on a chiral column of the constituent amino acids and by chemical synthesis of the polyamine moieties.

引用

页码：998 / 1006

页数：9

共 37 条

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