ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490I.: Taxonomy, fermentation, isolation and biological activities

被引：4
|
作者：
Inoue, H
Kumagai, H
Osono, M
Matsufuji, M
Sameshima, T
Kawamura, N
Someno, T
Ishizuka, M
Takeuchi, T
机构：
[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan
[2] Mercian Co Ltd, Bioresource Res Labs, Fujisawa, Kanagawa 2510057, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期
关键词：
D O I：
10.7164/antibiotics.56.209
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 mug/ml and showed weak cytotoxicity against bone marrow cells.
引用
收藏
页码：209 / 213
页数：5
相关论文
共 50 条
  • [31] New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties
    Narihiro Ugaki
    Daisuke Matsuda
    Hiroyuki Yamazaki
    Kenichi Nonaka
    Rokuro Masuma
    Satoshi Ōmura
    Hiroshi Tomoda
    The Journal of Antibiotics, 2012, 65 : 15 - 19
  • [32] TMC-86A, B and TMC-96, new proteasome inhibitors from Streptomyces sp TC 1084 and Saccharothrix sp TC 1094 -: I.: Taxonomy, fermentation, isolation, and biological activities
    Koguchi, Y
    Kohno, J
    Suzuki, S
    Nishio, M
    Takahashi, K
    Ohnuki, T
    Komatsubara, S
    JOURNAL OF ANTIBIOTICS, 1999, 52 (12): : 1069 - 1076
  • [33] New Aromatic Nitro Compounds from Salegentibacter sp. T436, an Arctic Sea Ice Bacterium: Taxonomy, Fermentation, Isolation and Biological Activities
    Wael Al-Zereini
    Imelda Schuhmann
    Hartmut Laatsch
    Elisabeth Helmke
    Heidrun Anke
    The Journal of Antibiotics, 2007, 60 : 301 - 308
  • [34] Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp Tu 6368 -: I.: Taxonomy, fermentation, isolation and biological activities
    Antal, N
    Fiedler, HP
    Stackebrandt, E
    Beil, W
    Ströch, K
    Zeeck, A
    JOURNAL OF ANTIBIOTICS, 2005, 58 (02): : 95 - 102
  • [35] Yaequinolones, New Insecticidal Antibiotics Produced by Penicillium sp. FKI-2140I. Taxonomy, Fermentation, Isolation and Biological Activity
    Ryuji Uchida
    Rie Imasato
    Yuichi Yamaguchi
    Rokuro Masuma
    Kazuro Shiomi
    Hiroshi Tomoda
    Satoshi Ōmura
    The Journal of Antibiotics, 2006, 59 : 646 - 651
  • [36] A new antimitotic substance, FRI82877 I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
    Sato, B
    Muramatsu, H
    Miyauchi, M
    Hori, Y
    Takase, S
    Hino, M
    Hashimoto, S
    Terano, H
    JOURNAL OF ANTIBIOTICS, 2000, 53 (02): : 123 - 130
  • [37] Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp TP-A0316 -: I.: Taxonomy, fermentation, isolation and biological properties
    Furumai, T
    Takagi, K
    Igarashi, Y
    Saito, N
    Oki, T
    JOURNAL OF ANTIBIOTICS, 2000, 53 (03): : 227 - 232
  • [38] WS-7528, A NEW ISOFLAVANONE WITH ESTROGEN ACTIVITY ISOLATED FROM STREPTOMYCES SP NO-7528 - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
    NAKAYAMA, O
    YAGI, M
    TANAKA, M
    KIYOTO, S
    UCHIDA, I
    HASHIMOTO, M
    OKUHARA, M
    KOHSAKA, M
    JOURNAL OF ANTIBIOTICS, 1990, 43 (11): : 1394 - 1402
  • [39] Taxonomy, fermentation, biological activities, isolation and characterization of metabolites obtained from a new strain of Streptomyces noursei (KC46)
    Krishnaveni, J.
    Radzom, M.
    Zeeck, A.
    Kishan, V.
    INDIAN JOURNAL OF BIOTECHNOLOGY, 2011, 10 (02): : 212 - 218
  • [40] Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities
    Hellwig, V
    Grothe, T
    Mayer-Bartschmid, A
    Endermann, R
    Geschke, FU
    Henkel, T
    Stadler, M
    JOURNAL OF ANTIBIOTICS, 2002, 55 (10): : 881 - 892
12345