A Coumarin-Based Fluorescent Probe as a Central Nervous System Disease Biomarker

被引：4
|
作者：
Yap, Ann-Chee [1 ]
Mahamad, Ummi Affah [2 ]
Lim, Shen-Yang [2 ]
Kim, Hae-Jo [3 ]
Choo, Yeun-Mun [1 ]
机构：
[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia
[3] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea
来源：
SENSORS | 2014年 / 14卷 / 11期
关键词：
fluorescent probe; fluorescence spectroscopy; mass spectrometry; homocysteine; methylmalonic acid; neurochemistry; chemoassay; PLASMA HOMOCYSTEINE LEVELS; METHYLMALONIC ACID; LEVODOPA; RECOGNITION; CYSTEINE; FOLATE;
D O I：
10.3390/s141121140
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Homocysteine and methylmalonic acid are important biomarkers for diseases associated with an impaired central nervous system (CNS). A new chemoassay utilizing coumarin-based fluorescent probe 1 to detect the levels of homocysteine is successfully implemented using Parkinson's disease (PD) patients' blood serum. In addition, a rapid identification of homocysteine and methylmalonic acid levels in blood serum of PD patients was also performed using the liquid chromatography-mass spectrometry (LC-MS). The results obtained from both analyses were in agreement. The new chemoassay utilizing coumarin-based fluorescent probe 1 offers a cost-and time-effective method to identify the biomarkers in CNS patients.
引用
收藏
页码：21140 / 21150
页数：11
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