Coumarin-based fluorescent probe for the detection of glutathione and nitroreductase

被引：5
|
作者：
Tian, Xue [1 ]
Kumawat, Lokesh K. [2 ,3 ]
Bull, Steven D. [1 ]
Elmes, Robert B. P. [2 ,3 ,4 ]
Wu, Luling [1 ]
James, Tony D. [1 ,5 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Natl Univ Ireland, Maynooth Univ, Dept Chem, Maynooth, Kildare, Ireland
[3] Natl Univ Ireland, Maynooth Univ, Kathleen Lonsdale Inst Human Hlth Res, Maynooth, Kildare, Ireland
[4] Maynooth Univ, Synth & Solid State Pharmaceut Ctr, Maynooth, Kildare, Ireland
[5] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
TETRAHEDRON | 2021年 / 82卷
基金：
英国工程与自然科学研究理事会; 爱尔兰科学基金会;
关键词：
Fluorescent probe; Nitroreductase; Glutathione;
D O I：
10.1016/j.tet.2020.131890
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
With this research we set out to develop a coumarin-based novel fluorescent probe NTR-AHC for the detection of biological thiols and nitroreductase (NTR). Probe NTR-AHC was constructed by attaching the NTR trigger moiety (p-nitrobenzyl) and biothiol acceptor (maleic acid monoamide), to the core fluorophore AHC. In the presence of both glutathione (GSH) and NTR, probe NTR-AHC produced a >8-fold increase in fluorescence intensity at 463 nm. (C) 2020 Published by Elsevier Ltd.
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页数：5
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