A Coumarin-Based Fluorescent Probe as a Central Nervous System Disease Biomarker

被引：4

作者：

Yap, Ann-Chee ^{[1
]}

Mahamad, Ummi Affah ^{[2
]}

Lim, Shen-Yang ^{[2
]}

Kim, Hae-Jo ^{[3
]}

Choo, Yeun-Mun ^{[1
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia

[3] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea

来源：

SENSORS | 2014年 / 14卷 / 11期

关键词：

fluorescent probe; fluorescence spectroscopy; mass spectrometry; homocysteine; methylmalonic acid; neurochemistry; chemoassay; PLASMA HOMOCYSTEINE LEVELS; METHYLMALONIC ACID; LEVODOPA; RECOGNITION; CYSTEINE; FOLATE;

D O I：

10.3390/s141121140

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Homocysteine and methylmalonic acid are important biomarkers for diseases associated with an impaired central nervous system (CNS). A new chemoassay utilizing coumarin-based fluorescent probe 1 to detect the levels of homocysteine is successfully implemented using Parkinson's disease (PD) patients' blood serum. In addition, a rapid identification of homocysteine and methylmalonic acid levels in blood serum of PD patients was also performed using the liquid chromatography-mass spectrometry (LC-MS). The results obtained from both analyses were in agreement. The new chemoassay utilizing coumarin-based fluorescent probe 1 offers a cost-and time-effective method to identify the biomarkers in CNS patients.

引用

页码：21140 / 21150

页数：11

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