4,4′-disubstituted-L-proline catalyzes the direct asymmetric Michael addition of aldehydes to nitrostyrenes

被引：52
|
作者：
Gu, Liu-qun [1 ]
Zhao, Gang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synth Organ Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 10期
关键词：
diastereoselectivity; 4-dimethylaminopyridine (DMAP); disubstituted-L-prolines; enantioselectivity; Michael addition; organocatalysis;
D O I：
10.1002/adsc.200600640
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In a search for small organic molecules as catalysts for the direct asymmetric Michael addition reaction of aldehydes to nitrostyrenes, 4,4'-di(naphthalene-1-ylmethyl)-L-proline 1c and a catalytic amount of 4-dimethylaminopyridine (DMAP) were found to be an efficient system for the Michael addition of aldehydes to nitrostyrenes with high diastereo- and enantioselectivity and broad substrate range.
引用
收藏
页码：1629 / 1632
页数：4
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