4,4′-disubstituted-L-proline catalyzes the direct asymmetric Michael addition of aldehydes to nitrostyrenes

被引：52

作者：

Gu, Liu-qun ^{[1
]}

Zhao, Gang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synth Organ Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 10期

关键词：

diastereoselectivity; 4-dimethylaminopyridine (DMAP); disubstituted-L-prolines; enantioselectivity; Michael addition; organocatalysis;

D O I：

10.1002/adsc.200600640

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In a search for small organic molecules as catalysts for the direct asymmetric Michael addition reaction of aldehydes to nitrostyrenes, 4,4'-di(naphthalene-1-ylmethyl)-L-proline 1c and a catalytic amount of 4-dimethylaminopyridine (DMAP) were found to be an efficient system for the Michael addition of aldehydes to nitrostyrenes with high diastereo- and enantioselectivity and broad substrate range.

引用

页码：1629 / 1632

页数：4

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