Novel NiZr-based porous biomaterials: Synthesis and in vitro testing

被引：22

作者：

Manukyan, Khachatur ^{[1
,4
]}

Amirkhanyan, Narine ^{[1
]}

Aydinyan, Sofiya ^{[1
]}

Danghyan, Vardan ^{[1
]}

Grigoryan, Ruzanna ^{[2
]}

Sarkisyan, Natalia ^{[2
]}

Gasparyan, Gennadi ^{[2
,3
]}

Aroutiounian, Rouben ^{[3
]}

Kharatyan, Suren ^{[1
,4
]}

机构：

[1] Yerevan State Univ, Dept Inorgan Chem, Yerevan 0025, Armenia

[2] Inst Mol Biol NAS Armenia, Grp Cytol, Yerevan 0014, Armenia

[3] Yerevan State Univ, Dept Genet & Cytol, Yerevan 0025, Armenia

[4] AB Nalbandyan Inst Chem Phys NAS Armenia, Lab Kinet SHS Proc, Yerevan 0014, Armenia

来源：

CHEMICAL ENGINEERING JOURNAL | 2010年 / 162卷 / 01期

关键词：

NiZr biomaterial; Combustion synthesis; Porosity; Cytotoxicity; Genotoxicity; HIGH-TEMPERATURE SYNTHESIS; SHAPE-MEMORY ALLOYS; COMBUSTION SYNTHESIS; NITI; FABRICATION; MECHANISM;

D O I：

10.1016/j.cej.2010.05.042

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Novel porous NiZr-based potential biomaterials for orthopaedic application were developed using the combustion reaction in the Ni + Zr + additive mixtures. The effect of various additives (ZrH2, CaCO3, NH4F and Teflon) on the combustion behaviour in the low-caloric Ni + Zr mixtures was investigated. To obtain molten porous NiZr-based product Teflon was chosen as an optimal additive. Combustion conditions of the Ni + Zr + Teflon mixtures depending on various factors were investigated. NiZr-based materials with 55-65% porosity and 50-550 mu m pore sizes were obtained. The cyto- and genotoxicity of the materials was tested in vitro using HeLa and KCL-22 cell lines. After several extractions the obtained porous materials expressed no toxicity. Produced materials were non-genotoxic and had no effect on the cell proliferation. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：406 / 414

页数：9

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