Novel NiZr-based porous biomaterials: Synthesis and in vitro testing

被引：22
|
作者：
Manukyan, Khachatur [1 ,4 ]
Amirkhanyan, Narine [1 ]
Aydinyan, Sofiya [1 ]
Danghyan, Vardan [1 ]
Grigoryan, Ruzanna [2 ]
Sarkisyan, Natalia [2 ]
Gasparyan, Gennadi [2 ,3 ]
Aroutiounian, Rouben [3 ]
Kharatyan, Suren [1 ,4 ]
机构：
[1] Yerevan State Univ, Dept Inorgan Chem, Yerevan 0025, Armenia
[2] Inst Mol Biol NAS Armenia, Grp Cytol, Yerevan 0014, Armenia
[3] Yerevan State Univ, Dept Genet & Cytol, Yerevan 0025, Armenia
[4] AB Nalbandyan Inst Chem Phys NAS Armenia, Lab Kinet SHS Proc, Yerevan 0014, Armenia
来源：
CHEMICAL ENGINEERING JOURNAL | 2010年 / 162卷 / 01期
关键词：
NiZr biomaterial; Combustion synthesis; Porosity; Cytotoxicity; Genotoxicity; HIGH-TEMPERATURE SYNTHESIS; SHAPE-MEMORY ALLOYS; COMBUSTION SYNTHESIS; NITI; FABRICATION; MECHANISM;
D O I：
10.1016/j.cej.2010.05.042
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Novel porous NiZr-based potential biomaterials for orthopaedic application were developed using the combustion reaction in the Ni + Zr + additive mixtures. The effect of various additives (ZrH2, CaCO3, NH4F and Teflon) on the combustion behaviour in the low-caloric Ni + Zr mixtures was investigated. To obtain molten porous NiZr-based product Teflon was chosen as an optimal additive. Combustion conditions of the Ni + Zr + Teflon mixtures depending on various factors were investigated. NiZr-based materials with 55-65% porosity and 50-550 mu m pore sizes were obtained. The cyto- and genotoxicity of the materials was tested in vitro using HeLa and KCL-22 cell lines. After several extractions the obtained porous materials expressed no toxicity. Produced materials were non-genotoxic and had no effect on the cell proliferation. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：406 / 414
页数：9
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