Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: II.: Structural studies

被引：23
|
作者：
Hori, H [1 ]
Igarashi, Y
Kajiura, T
Furumai, T
Higashi, K
Ishiyama, T
Uramoto, M
Uehara, Y
Oka, T
机构：
[1] Tamagawa Univ, Fac Agr, Tokyo 1948610, Japan
[2] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan
[3] Natl Inst Infect Dis, Dept Bioact Mol, Shinjuku Ku, Tokyo 1620052, Japan
来源：
JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 04期
关键词：
D O I：
10.7164/antibiotics.51.402
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
引用
收藏
页码：402 / 417
页数：16
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