In Vitro Activity of a New Isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and Other Mycobacteria

被引：11

作者：

Molina-Torres, Carmen A. ^{[1
]}

Ocampo-Candiani, Jorge ^{[1
]}

Rendon, Adrian ^{[2
]}

Pucci, Michael J. ^{[3
]}

Vera-Cabrera, Lucio ^{[1
]}

机构：

[1] Hosp Univ Jose E Gonzalez, Serv Dermatol, Monterrey 64460, NL, Mexico

[2] Hosp Univ Jose E Gonzalez, TB Clin, CIPTIR, Monterrey 64460, NL, Mexico

[3] Achill Pharmaceut Inc, New Haven, CT USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期

关键词：

POTENT ANTIBACTERIAL AGENTS; VIVO ACTIVITIES; ANTIMYCOBACTERIAL DRUGS; AVIUM COMPLEX; FLUOROQUINOLONES; GATIFLOXACIN; MOXIFLOXACIN; CLARITHROMYCIN; CIPROFLOXACIN; 7-POSITION;

D O I：

10.1128/AAC.01603-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC(50) and MIC(90) of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 mu g/ml, respectively. The MIC(50) and MIC(90) values for Mycobacterium fortuitum isolates were 0.0625 mu g/ml in both cases; Mycobacterium avium complex isolates showed MIC(50) and MIC(90) values of 0.25 and 4 mu g/ml, respectively.

引用

页码：2188 / 2190

页数：3

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