In Vitro Activity of a New Isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and Other Mycobacteria

被引：11
|
作者：
Molina-Torres, Carmen A. [1 ]
Ocampo-Candiani, Jorge [1 ]
Rendon, Adrian [2 ]
Pucci, Michael J. [3 ]
Vera-Cabrera, Lucio [1 ]
机构：
[1] Hosp Univ Jose E Gonzalez, Serv Dermatol, Monterrey 64460, NL, Mexico
[2] Hosp Univ Jose E Gonzalez, TB Clin, CIPTIR, Monterrey 64460, NL, Mexico
[3] Achill Pharmaceut Inc, New Haven, CT USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期
关键词：
POTENT ANTIBACTERIAL AGENTS; VIVO ACTIVITIES; ANTIMYCOBACTERIAL DRUGS; AVIUM COMPLEX; FLUOROQUINOLONES; GATIFLOXACIN; MOXIFLOXACIN; CLARITHROMYCIN; CIPROFLOXACIN; 7-POSITION;
D O I：
10.1128/AAC.01603-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC(50) and MIC(90) of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 mu g/ml, respectively. The MIC(50) and MIC(90) values for Mycobacterium fortuitum isolates were 0.0625 mu g/ml in both cases; Mycobacterium avium complex isolates showed MIC(50) and MIC(90) values of 0.25 and 4 mu g/ml, respectively.
引用
收藏
页码：2188 / 2190
页数：3
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