Dipeptide-catalyzed direct asymmetric aldol reaction

被引：82
|
作者：
Shi, LX [1 ]
Sun, Q [1 ]
Ge, ZM [1 ]
Zhu, YQ [1 ]
Cheng, TM [1 ]
Li, RT [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
来源：
SYNLETT | 2004年 / 12期
关键词：
aldol reaction; organocatalysis; enamine catalysis; dipeptides;
D O I：
10.1055/s-2004-831324
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(L)-H-Pro-(L)-Phe-OH (4) were found to be efficient catalysts for direct asymmetric aldol reactions between acetone and various aldehydes. The reaction conditions use a DMSO-NMM-PEMG 5000 system at 0 degreesC in high yields (62-96%) and enantioselectivities (up to >99% ee).
引用
收藏
页码：2215 / 2217
页数：3
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