Dipeptide-catalyzed direct asymmetric aldol reaction

被引：82

作者：

Shi, LX ^{[1
]}

Sun, Q ^{[1
]}

Ge, ZM ^{[1
]}

Zhu, YQ ^{[1
]}

Cheng, TM ^{[1
]}

Li, RT ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

来源：

SYNLETT | 2004年 / 12期

关键词：

aldol reaction; organocatalysis; enamine catalysis; dipeptides;

D O I：

10.1055/s-2004-831324

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(L)-H-Pro-(L)-Phe-OH (4) were found to be efficient catalysts for direct asymmetric aldol reactions between acetone and various aldehydes. The reaction conditions use a DMSO-NMM-PEMG 5000 system at 0 degreesC in high yields (62-96%) and enantioselectivities (up to >99% ee).

引用

页码：2215 / 2217

页数：3

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