Cationic Micelles Based on Polyhedral Oligomeric Silsesquioxanes for Enhanced Gene Transfection

被引：21
|
作者：
Liu, Connie K. [1 ]
Dou, Qingqing [1 ]
Liow, Sing Shy [1 ]
Kumar, Jatin N. [1 ]
Loh, Xian Jun [1 ,2 ,3 ]
机构：
[1] ASTAR, Inst Mat Res & Engn, 2 Fusionopolis Way,Innovis,08-03, Singapore 138634, Singapore
[2] Natl Univ Singapore, Dept Mat Sci & Engn, 9 Engn Dr 1, Singapore 117576, Singapore
[3] Singapore Eye Res Inst, 11 Third Hosp Ave, Singapore 168751, Singapore
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2016年 / 69卷 / 04期
关键词：
DELIVERY-SYSTEMS; DRUG-DELIVERY; VIRAL VECTORS; POLY(2-DIMETHYLAMINOETHYL METHACRYLATE); NONVIRAL VECTORS; CO-DELIVERY; IN-VITRO; THERAPY; NANOPARTICLES; COPOLYMERS;
D O I：
10.1071/CH15636
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis and gene transfection efficiency of a series of amphiphilic copolymers, poly(2-(dimethylamino)ethyl methacrylate)-poly (methacrylate isobutyl polyhedral oligomeric silsesquioxane) (PDMAEMA-POSS) copolymers are reported. The hydrophobic POSS interior allows a cell-sensitizing drug such as paclitaxel to be incorporated, whereas the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency compared with polyethylenimine or PDMAEMA homopolymers.
引用
收藏
页码：363 / 371
页数：9
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