Cationic Micelles Based on Polyhedral Oligomeric Silsesquioxanes for Enhanced Gene Transfection

被引：21

作者：

Liu, Connie K. ^{[1
]}

Dou, Qingqing ^{[1
]}

Liow, Sing Shy ^{[1
]}

Kumar, Jatin N. ^{[1
]}

Loh, Xian Jun ^{[1
,2
,3
]}

机构：

[1] ASTAR, Inst Mat Res & Engn, 2 Fusionopolis Way,Innovis,08-03, Singapore 138634, Singapore

[2] Natl Univ Singapore, Dept Mat Sci & Engn, 9 Engn Dr 1, Singapore 117576, Singapore

[3] Singapore Eye Res Inst, 11 Third Hosp Ave, Singapore 168751, Singapore

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2016年 / 69卷 / 04期

关键词：

DELIVERY-SYSTEMS; DRUG-DELIVERY; VIRAL VECTORS; POLY(2-DIMETHYLAMINOETHYL METHACRYLATE); NONVIRAL VECTORS; CO-DELIVERY; IN-VITRO; THERAPY; NANOPARTICLES; COPOLYMERS;

D O I：

10.1071/CH15636

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and gene transfection efficiency of a series of amphiphilic copolymers, poly(2-(dimethylamino)ethyl methacrylate)-poly (methacrylate isobutyl polyhedral oligomeric silsesquioxane) (PDMAEMA-POSS) copolymers are reported. The hydrophobic POSS interior allows a cell-sensitizing drug such as paclitaxel to be incorporated, whereas the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency compared with polyethylenimine or PDMAEMA homopolymers.

引用

页码：363 / 371

页数：9

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