Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

被引：78

作者：

Loh, Xian Jun ^{[1
]}

Zhang, Zhong-Xing ^{[1
]}

Mya, Khine Yi ^{[1
]}

Wu, Yun-long ^{[2
]}

He, Chao Bin ^{[1
]}

Li, Jun ^{[1
,2
]}

机构：

[1] ASTAR, IMRE, Singapore 117602, Singapore

[2] NUS, Div Bioengn, Fac Engn, Singapore 117574, Singapore

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2010年 / 20卷 / 47期

关键词：

BIODEGRADABLE COPOLYMER; TRANSGENE EXPRESSION; CO-DELIVERY; VECTORS; POLYETHYLENEIMINE; NANOCOMPOSITES; TRANSFECTION; MICELLES; POLYMERS; CELLS;

D O I：

10.1039/c0jm01461c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We present a novel hybrid cationic polymer based on polyhedral oligomeric silsesquioxanes (POSS). This is the first report of using a cationic POSS-based material for gene delivery. Due to its amphiphilic properties, hydrophobic drugs such as paclitaxel can be encapsulated within the hydrophobic core of this polymer. In this paper, it is shown that paclitaxel-encapsulated hybrid POSS-based polyplexes show superior gene transfection efficiency in human breast cancer cells than the non drug-loaded polyplexes.

引用

页码：10634 / 10642

页数：9

共 3 条

[1] Cationic Micelles Based on Polyhedral Oligomeric Silsesquioxanes for Enhanced Gene Transfection
Liu, Connie K.
Dou, Qingqing
Liow, Sing Shy
Kumar, Jatin N.
Loh, Xian Jun
AUSTRALIAN JOURNAL OF CHEMISTRY, 2016, 69 (04) : 363 - 371
[2] POSS-based hybrid cationic copolymers with low aggregation potential for efficient gene delivery
Jiang, Shan
Poh, Ying Zhou
Loh, Xian Jun
RSC ADVANCES, 2015, 5 (87): : 71322 - 71328
[3] Novel Cholesterol-Based Cationic Lipids as Transfecting Agents of DNA for Efficient Gene Delivery
Ju, Jia
Huan, Meng-Lei
Wan, Ning
Qiu, Hai
Zhou, Si-Yuan
Zhang, Bang-Le
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (03): : 5666 - 5681

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