Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

被引：1
|
作者：
Lipka, Joanna [1 ]
Hoogenraad, Casper C. [1 ]
机构：
[1] Genentech Inc, Dept Neurosci, San Francisco, CA 94080 USA
来源：
NEURON | 2019年 / 104卷 / 03期
关键词：
D O I：
10.1016/j.neuron.2019.10.021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.
引用
收藏
页码：429 / 430
页数：2
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