Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

被引：1

作者：

Lipka, Joanna ^{[1
]}

Hoogenraad, Casper C. ^{[1
]}

机构：

[1] Genentech Inc, Dept Neurosci, San Francisco, CA 94080 USA

来源：

NEURON | 2019年 / 104卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2019.10.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

引用

页码：429 / 430

页数：2

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