Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants

被引：20
|
作者：
Cancio, Reynel
Mai, Antonello
Rotili, Dante
Artico, Marino
Sbardella, Gianluca
Clotet-Codina, Imma
Este, Jose A.
Crespan, Emmanuele
Zanoli, Samantha
Hubscher, Ulrich
Spadari, Silvio
Maga, Giovanni
机构：
[1] Istituto di Genetica Molecolare, Consiglio Nazionale Delle Ricerche, 27100 Pavia
[2] Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, 00185 Roma
[3] Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, 84084 Fisciano (SA), via Ponte Don Melillo
[4] Retrovirology Laboratory IrsiCaixa, Hospital Universitari Germans Trias I Pujol, Universitat AutAnoma de Barcelona
[5] Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, 8057 Zürich
来源：
CHEMMEDCHEM | 2007年 / 2卷 / 04期
关键词：
D O I：
10.1002/cmdc.200600310
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(Chemical Equation Presented) A new series of dihydro-alkylaminobenzyl- oxopyrimidines (N,N-DABOs) showing a broad activity spectrum against NNRTI-resistant mutants have been reported. Such compounds display a slow, tight binding to HIV-1 RT. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：445 / 448
页数：4
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