Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants

被引：20

作者：

Cancio, Reynel

Mai, Antonello

Rotili, Dante

Artico, Marino

Sbardella, Gianluca

Clotet-Codina, Imma

Este, Jose A.

Crespan, Emmanuele

Zanoli, Samantha

Hubscher, Ulrich

Spadari, Silvio

Maga, Giovanni

机构：

[1] Istituto di Genetica Molecolare, Consiglio Nazionale Delle Ricerche, 27100 Pavia

[2] Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, 00185 Roma

[3] Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, 84084 Fisciano (SA), via Ponte Don Melillo

[4] Retrovirology Laboratory IrsiCaixa, Hospital Universitari Germans Trias I Pujol, Universitat AutAnoma de Barcelona

[5] Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, 8057 Zürich

来源：

CHEMMEDCHEM | 2007年 / 2卷 / 04期

关键词：

D O I：

10.1002/cmdc.200600310

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Chemical Equation Presented) A new series of dihydro-alkylaminobenzyl- oxopyrimidines (N,N-DABOs) showing a broad activity spectrum against NNRTI-resistant mutants have been reported. Such compounds display a slow, tight binding to HIV-1 RT. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：445 / 448

页数：4

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