Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes

被引：25
|
作者：
Fei, Bao-Li [1 ,2 ]
Li, Wen [1 ]
Xu, Wu-Shuang [1 ]
Long, Jian-Ying [3 ]
Liu, Qing-Bo [3 ]
Sun, Wei-Yin [2 ]
Anson, Christopher E. [4 ]
Powell, Annie K. [4 ]
机构：
[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China
[2] Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China
[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Jiangsu, Peoples R China
[4] Karlsruhe Inst Technol, Inst Inorgan Chem, D-76131 Karlsruhe, Germany
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2013年 / 34期
关键词：
Cytotoxicity; DNA binding; Copper; Structure elucidation; Chirality; CU-II; NI-II; LIGAND; CU(II); CLEAVAGE; ZN(II); ANTIOXIDANT; NI(II);
D O I：
10.1002/ejic.201300685
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two chiral copper-(II) complexes [Cu(L)(2)Cl]Cl (1) and [Cu(L)(2)Br]Br (2) [L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu-II ions in 1 and 2 can be described as an intermediate between squarepyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA. through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential.
引用
收藏
页码：5919 / 5927
页数：9
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