Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand

被引：9
|
作者：
Sathiyaraj, Subbaiyan [1 ]
Sampath, Krishnan [1 ]
Butcher, Ray J. [2 ]
Jayabalakrishnan, Chinnasamy [1 ]
机构：
[1] Sri Ramakrishna Mission Vidyalaya Coll Arts & Sci, Post Grad & Res Dept Chem, Coimbatore 641020, Tamil Nadu, India
[2] Howard Univ, Dept Chem, Washington, DC 20059 USA
来源：
TRANSITION METAL CHEMISTRY | 2013年 / 38卷 / 03期
关键词：
IN-VITRO;
D O I：
10.1007/s11243-013-9690-z
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Three ruthenium(II) complexes, [Ru(CO)Cl(PPh3)L], [Ru(CO)Cl(AsPh3)L] and [Ru(CO)Cl(Py)L], were synthesized from the reactions of 2-(benzothiazol-2-yliminomethyl)-phenol (HL) with [RuHCl(CO)B(EPh3)(2)], where B = PPh3, AsPh3 or pyridine, and E = P or As. All the complexes have been characterized by physicochemical and spectroscopic methods. The structure of the free ligand HL was determined by single crystal X-ray diffraction. The binding of the free ligand and its complexes with CT-DNA was studied using electronic absorption spectroscopy. In addition, the free ligand and its complexes were subjected to antioxidant activity tests, which showed that they all possess significant scavenging effects against DPPH and OH radicals. The in vitro cytotoxicities of the compounds were assessed using tumor (HeLa and MCF-7) cell lines.
引用
收藏
页码：291 / 298
页数：8
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