New secoiridoids from the fruits of Ligustrum lucidum

被引：12

作者：

Qiu, Zuo-Cheng ^{[1
]}

Zhao, Xiao-Xiao ^{[1
]}

Wu, Qing-Chang ^{[1
]}

Fu, Jian-Wu ^{[2
]}

Dai, Yi ^{[1
,2
]}

Wong, Man-Sau ^{[3
]}

Yao, Xin-Sheng ^{[1
,2
,4
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[2] Key Lab Standard Mat Nat Med Guangdong Prov, Guangzhou 510530, Guangdong, Peoples R China

[3] Hong Kong Polytech Univ, Shenzhen Res Inst, State Key Lab Chinese Med & Mol Pharmacol, Shenzhen 518057, Peoples R China

[4] Shenyang Pharmaceut Univ, Coll Tradit Chinese Med, Shenyang 110016, Liaoning, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Oleaceae; secoiridoids; ligustri lucidi fructus; MC3T3-E1; cells; osteogenic activity; IN-VITRO; FRUCTUS; EXTRACT; ACID;

D O I：

10.1080/10286020.2018.1454438

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells. [GRAPHICS] .

引用

页码：431 / 438

页数：8

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