New secoiridoids from the fruits of Ligustrum lucidum Ait with triglyceride accumulation inhibitory effects

被引：24

作者：

Zhang, Yi ^{[1
]}

Liu, Lili ^{[2
]}

Gao, Jing ^{[2
]}

Wu, Chunhua ^{[2
]}

Han, Lifeng ^{[2
]}

Liu, Erwei ^{[2
]}

Shi, Pingping ^{[2
]}

Gao, Xiumei ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

机构：

[1] Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China

来源：

FITOTERAPIA | 2013年 / 91卷

基金：

中国国家自然科学基金;

关键词：

Ligustrum lucidum; Secoiridoids; Triglyceride accumulation inhibitory effects; HepG2; cells; CONSTITUENTS; GLUCOSIDES; GLYCOSIDES;

D O I：

10.1016/j.fitote.2013.08.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new secoiridoids, nuzhenal C (1), 6'-O-trans-cinnamoyl iso-8-epikingisidic acid (2), ligulucidumosides A (3), B (4), and C (5), were obtained from the fruits of Ligustrum lucidum Ait. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compound 3 is the first 1-OCH3 substituent secoiridoid obtained from plant kingdom. Furthermore, activity screening results showed that all of the isolates had triglyceride accumulation inhibitory effects in HepG2 cells. (C) 2013 Published by Elsevier B.V.

引用

页码：107 / 112

页数：6

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