In Vitro Evaluation of Paclitaxel Loaded Magnetic Nanoparticles for Breast Cancer Therapy

被引：0

作者：

Ursachi, V. C. ^{[1
,2
]}

Mihai, C. T. ^{[3
]}

Nastuta, A. ^{[1
]}

Dimitriu, C. D. ^{[4
]}

Verestiuc, L. ^{[1
]}

Balan, V ^{[1
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Fac Med Bioengn, 9-13 Kogalniceanu St, Iasi 700454, Romania

[2] Petra Poni Inst Macromol Chem, Nat Polymers Bioact & Biocompatible Mat Lab, Iasi 700487, Romania

[3] Grigore T Popa Univ Med & Pharm, Adv Ctr Res Dev Expt Med, Iasi, Romania

[4] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Morphol & Funct Sci, Iasi, Romania

来源：

2021 INTERNATIONAL CONFERENCE ON E-HEALTH AND BIOENGINEERING (EHB 2021), 9TH EDITION | 2021年

关键词：

magnetic nanoparticles; breast cancer; Paclitaxel; biotinylated N-palmitoyl chitosan; IRON-OXIDE NANOPARTICLES; BIOTIN;

D O I：

10.1109/EHB52898.2021.9657671

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

This paper presents in vitro evaluation of several characteristics of Paclitaxel loaded magnetic nanoparticles based on iron oxide nanosferes and biotinylated N-palmitoyl chitosan for potential applications as drug delivery system in breast cancer therapy. Obtained magnetic nanoparticles were dispersible in glucose solution (10 %), induced apoptosis in MDA-MB-231 cells and they did not determine notable modification of the coagulation parameter (time of partially activated thromboplastin-APTT) after the contact with blood. In the presence of a magnetic field, the nanoparticles aligned in the direction of the field lines.

引用

页数：4

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