In Vitro Evaluation of Paclitaxel Loaded Magnetic Nanoparticles for Breast Cancer Therapy

This paper presents in vitro evaluation of several characteristics of Paclitaxel loaded magnetic nanoparticles based on iron oxide nanosferes and biotinylated N-palmitoyl chitosan for potential applications as drug delivery system in breast cancer therapy. Obtained magnetic nanoparticles were dispersible in glucose solution (10 %), induced apoptosis in MDA-MB-231 cells and they did not determine notable modification of the coagulation parameter (time of partially activated thromboplastin-APTT) after the contact with blood. In the presence of a magnetic field, the nanoparticles aligned in the direction of the field lines.