A rotaxane-like complex with controlled-release characteristics

被引：51
|
作者：
Chiu, SH [1 ]
Rowan, SJ [1 ]
Cantrill, SJ [1 ]
Glink, PT [1 ]
Garrell, RL [1 ]
Stoddart, JF [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 23期
关键词：
D O I：
10.1021/ol006525d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A rotaxane-like complex, based on a dumbbell-shaped component containing an NH2+ recognition site for a [25]crown-8 ring component and a slippage stopper in the form of a p(tert-butyl)phenyl group, has been synthesized by a "threading-followed-by-stoppering" approach. The half-life for dissociation of this complex, which is very sensitive to its environment, can be varied from minutes to months by changing the temperature and the polarity of the solvent.
引用
收藏
页码：3631 / 3634
页数：4
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