A rotaxane-like complex with controlled-release characteristics

被引：51

作者：

Chiu, SH ^{[1
]}

Rowan, SJ ^{[1
]}

Cantrill, SJ ^{[1
]}

Glink, PT ^{[1
]}

Garrell, RL ^{[1
]}

Stoddart, JF ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006525d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A rotaxane-like complex, based on a dumbbell-shaped component containing an NH2+ recognition site for a [25]crown-8 ring component and a slippage stopper in the form of a p(tert-butyl)phenyl group, has been synthesized by a "threading-followed-by-stoppering" approach. The half-life for dissociation of this complex, which is very sensitive to its environment, can be varied from minutes to months by changing the temperature and the polarity of the solvent.

引用

页码：3631 / 3634

页数：4

共 50 条

[21] A controlled-release microchip
Santini, JT
Cima, MJ
Langer, R
NATURE, 1999, 397 (6717) : 335 - 338
[22] CONTROLLED-RELEASE PESTICIDES
SONNET, PE
BEE WORLD, 1978, 59 (03) : 112 - 114
[23] A controlled-release microchip
Department of Chemical Engineering, Massachusetts Inst. of Technology, Cambridge, MA 02139, United States
不详
Nature, 6717 (335-338):
[24] Controlled-release carvedilol
Carter, Natalie J.
Keating, Gillian M.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2008, 8 (04) : 271 - 282
[25] Controlled-release oxycodone
Pasero, C
McCaffery, M
AMERICAN JOURNAL OF NURSING, 2004, 104 (01) : 30 - 32
[26] A controlled-release microchip
John T. Santini
Michael J. Cima
Robert Langer
Nature, 1999, 397 : 335 - 338
[27] Controlled-Release Carvedilol
Natalie J. Carter
Gillian M. Keating
American Journal of Cardiovascular Drugs, 2008, 8 : 271 - 282
[28] Controlled-release microchips
Sharma, Sadhana
Nijdam, A. Jasper
Sinha, Piyush M.
Walczak, Robbie J.
Liu, Xuewu
Cheng, Mark M-C
Ferrari, Mauro
EXPERT OPINION ON DRUG DELIVERY, 2006, 3 (03) : 379 - 394
[29] CONTROLLED-RELEASE LEVODOPA
BLUMENTHAL, HJ
NEUROLOGY, 1993, 43 (12) : 2728 - 2729
[30] Spectral and photophysical studies of the 1:3 (guest/host) rotaxane-like inclusion complex formed by a 3H-indole and β-cyclodextrin
Shen, XH
Belletête, M
Durocher, G
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (11): : 1877 - 1883

← 1 2 3 4 5 →