Fc-silenced bispecific antibodies targeting PD-L1 and 4-1BB combine checkpoint blockade and T-cell co-stimulation to promote anti-tumor activity

被引：0

作者：

Muik, Alexander ^{[1
]}

Altintas, Isil ^{[2
]}

Gieseke, Friederike ^{[1
]}

Salcedo, Theodora ^{[2
]}

Burm, Saskia ^{[2
]}

Diken, Mustafa ^{[1
]}

Grunwitz, Christian ^{[1
]}

Schuurhuis, Danita ^{[2
]}

Kreiter, Sebastian ^{[1
]}

Satijn, David ^{[2
]}

Tureci, Ozlem ^{[1
]}

Breij, Esther ^{[2
]}

Sahin, Ugur ^{[1
]}

Jure-Kunkel, Maria ^{[2
]}

机构：

[1] BioNTech SE, Mainz, Germany

[2] Genmab, Utrecht, Netherlands

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2019年 / 7卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P609

引用

页数：2

共 50 条

[21] Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation
Myers, LM
Vella, AT
TRENDS IN IMMUNOLOGY, 2005, 26 (08) : 440 - 446
[22] BH3120, PD-L1 X 4-1BB bispecific antibody, plus PD-1 antagonist results in synergistic anti-tumor efficacy with excellent safety profile
Wang, Jun
Wang, Jing
Liu, Yang
Xu, Jiangcheng
Liu, Jiawang
Lee, Kyoungwoo
CANCER RESEARCH, 2024, 84 (06)
[23] Simultaneous costimulatory T-cell engagement and checkpoint inhibition by PRS-344/S095012, a PD-L1 / 4-1BB bispecific compound for tumor localized activation of the immune system.
Morales-Kastresana, Aizea
Pavlidou, Marina
Peper, Janet
Pattarini, Lucia
Barthels, Christian
Hansbauer, Eva-Maria
Aiba, Rachida Bel
Bossenmaier, Birgit
Scholer-Dahirel, Alix
Jaquin, Thomas
Gallou, Catherine
Blanc, Veronique
Rothe, Christine
Olwill, Shane
CANCER RESEARCH, 2021, 81 (13)
[24] PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy
Karwacz, Katarzyna
Arce, Frederick
Bricogne, Christopher
Kochan, Grazyna
Escors, David
ONCOIMMUNOLOGY, 2012, 1 (01): : 86 - 88
[25] ABL503 (TJ-L14B), PD-L1X4-1BB BISPECIFIC ANTIBODY INDUCES SUPERIOR ANTI-TUMOR ACTIVITY BY PD-L1-DEPENDENT 4-1BB ACTIVATION WITH THE INCREASE OF 4-1BB+CD8+T CELLS IN TUMOR MICROENVIRONMENT
Jung, Uijung
Jeon, Jaehyoung
Lee, Shinai
Jin, Hyung-Seung
Kim, Youngkwang
Sung, Eunsil
Kim, Hyunjoo
Lim, Yangmi
Won, Jonghwa
Wang, Zhengyi
Jiang, Wenqing
Jung, Jaeho
You, Gihoon
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A935 - A935
[26] Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist
Haenel, Gerulf
Neumann, Anne-Sophie
Pulko, Vesna
Claus, Christina
Leutbecher, Alexandra
Marcinek, Anetta
Zieger, Nora
Buecklein, Veit L.
Umana, Pablo
Klein, Christian
Subklewe, Marion
BLOOD, 2021, 138
[27] The PD-L1/4-1BB Bispecific Antibody-Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner
Peper-Gabriel, Janet K.
Pavlidou, Marina
Pattarini, Lucia
Morales-Kastresana, Aizea
Jaquin, Thomas J.
Gallou, Catherine
Hansbauer, Eva-Maria
Richter, Marleen
Lelievre, Helene
Scholer-Dahirel, Alix
Bossenmaier, Birgit
Sancerne, Celine
Riviere, Matthieu
Grandclaudon, Maximilien
Zettl, Markus
Aiba, Rachida S. Bel
Rothe, Christine
Blanc, Veronique
Olwill, Shane A.
CLINICAL CANCER RESEARCH, 2022, 28 (15) : 3387 - 3399
[28] A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
Cecile Geuijen
Paul Tacken
Liang-Chuan Wang
Rinse Klooster
Pieter Fokko van Loo
Jing Zhou
Arpita Mondal
Yao-bin Liu
Arjen Kramer
Thomas Condamine
Alla Volgina
Linda J. A. Hendriks
Hans van der Maaden
Eric Rovers
Steef Engels
Floris Fransen
Renate den Blanken-Smit
Vanessa Zondag-van der Zande
Abdul Basmeleh
Willem Bartelink
Ashwini Kulkarni
Wilfred Marissen
Cheng-Yen Huang
Leslie Hall
Shane Harvey
Soyeon Kim
Marina Martinez
Shaun O’Brien
Edmund Moon
Steven Albelda
Chrysi Kanellopoulou
Shaun Stewart
Horacio Nastri
Alexander B. H. Bakker
Peggy Scherle
Ton Logtenberg
Gregory Hollis
John de Kruif
Reid Huber
Patrick A. Mayes
Mark Throsby
Nature Communications, 12
[29] A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response
Rubio-Perez, Laura
Lazaro-Gorines, Rodrigo
Harwood, Seandean L.
Compte, Marta
Navarro, Rocio
Tapia-Galisteo, Antonio
Bonet, Jaume
Blanco, Belen
Lykkemark, Simon
Ramirez-Fernandez, Angel
Ferreras-Gutierrez, Mariola
Dominguez-Alonso, Carmen
Diez-Alonso, Laura
Segura-Tudela, Alejandro
Hangiu, Oana
Erce-Llamazares, Ainhoa
Blanco, Francisco J.
Santos, Cruz
Rodriguez-Peralto, Jose L.
Sanz, Laura
Alvarez-Vallina, Luis
ONCOIMMUNOLOGY, 2023, 12 (01):
[30] Glutaminase inhibition with CB-839 enhances anti-tumor activity of PD-1 and PD-L1 antibodies by overcoming a metabolic checkpoint blocking T cell activation
Gross, Matt
Chen, Jason
Engler, Judd
Janes, Julie
Leone, Robert
MacKinnon, Andy
Parlati, Francesco
Rodriquez, Mirna
Shwonek, Peter
Powell, Jonathan
CANCER RESEARCH, 2016, 76

← 1 2 3 4 5 →