Determination of HbA1c in the presence of haemoglobin variants:: Comparison of three HPLC techniques

被引：0

作者：

Carta, M ^{[1
]}

Dall'Olio, G ^{[1
]}

Soffiati, G ^{[1
]}

机构：

[1] Osped S Bortolo, Chim Clin & Ematol Lab, I-36100 Vicenza, Italy

来源：

EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY | 1997年 / 35卷 / 12期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of Hb variants may cause analytical interference in HbA(1c), values measured with the HPLC techniques currently used in Italian laboratories. In this study performance of a new HPLC system, (HA-8140, Menarini) was compared with two other traditional HPLC systems (HA-8121, Menarini and Diamat, Bio-Rad). The HA-8140 system detects the Kb variant possibly present in an independent peak. The integration area of such a peak is not computed in the calculation of the percentage value of HbA(1c). In this manner the underestimation of values obtained with traditional HPLC systems is avoided.

引用

页码：923 / 925

页数：3

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