A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent

被引：0

作者：

Hartley, JA

Hazrati, A

Kelland, LR

Khanim, R

Shipman, M

Suzenet, F

Walker, LF

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Dept Oncol, CRC Drug DNA Interact Res Grp, London W1P 8BT, England

[2] Inst Canc Res, CRC Ctr Canc Therapeut, Surrey SM2 2NG, England

[3] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 19期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

下载

页码：3467 / +

页数：5

共 35 条

[31] Structural features of novel dimeric quinacrines that have single-agent antitumor activity determine the mechanism of action: destabilization of mTORC1/lysosomal interaction versus DNA damage
Rebecca, Vito W.
Nicastri, Michael
McGlaughlin, Noel
McAfee, Quentin
Zhang, Gao
Alicea, Gretchen M.
Piao, Shengfu
Fennelly, Colin
Murugan, Sengottuvelan
Wei, Zhi
Mills, Gordon B.
Lu, Yiling
Herlyn, Meenhard
Winkler, Jeffrey A.
Amaravadi, Ravi K.
CANCER RESEARCH, 2016, 76
[32] SEQUENCE-SPECIFIC AND MECHANISM-BASED CROSS-LINKING OF DCM DNA CYTOSINE-C5 METHYLTRANSFERASE OF ESCHERICHIA-COLI K-12 TO SYNTHETIC OLIGONUCLEOTIDES CONTAINING 5-FLUORO-2'-DEOXYCYTIDINE
HANCK, T
SCHMIDT, S
FRITZ, HJ
NUCLEIC ACIDS RESEARCH, 1993, 21 (02) : 303 - 309
[33] De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines - Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality
Bunting, KD
Townsend, AJ
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (20) : 11884 - 11890
[34] De Novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines: Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality
Biochemistry Department, Bowman Gray Sch. Med., Wake Forest, Univ. Comprehensive Cancer Center, Winston-Salem, NC 27157, United States
不详
不详
J. Biol. Chem., 20 (11884-11890):
[35] The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill
Pepper, CJ
Hambly, RM
Fegan, CD
Delavault, P
Thurston, DE
CANCER RESEARCH, 2004, 64 (18) : 6750 - 6755

← 1 2 3 4 →