A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent

被引：0
|
作者：
Hartley, JA
Hazrati, A
Kelland, LR
Khanim, R
Shipman, M
Suzenet, F
Walker, LF
机构：
[1] UCL, Royal Free & Univ Coll Med Sch, Dept Oncol, CRC Drug DNA Interact Res Grp, London W1P 8BT, England
[2] Inst Canc Res, CRC Ctr Canc Therapeut, Surrey SM2 2NG, England
[3] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 19期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
下载
收藏
页码：3467 / +
页数：5
相关论文
共 35 条
  • [21] Novel Antitumor Indolizino[6,7-b]indoles with Multiple Modes of Action: DNA Cross-Linking and Topoisomerase I and II Inhibition
    Chaniyara, Ravi
    Tala, Satishkumar
    Chen, Chi-Wei
    Zang, Xiuguo
    Kakadiya, Rajesh
    Lin, Li-Fang
    Chen, Ching-Huang
    Chien, Shin-I
    Chou, Ting-Chao
    Tsai, Tung-Hu
    Lee, Te-Chang
    Shah, Anamik
    Su, Tsann-Long
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (04) : 1544 - 1563
  • [22] Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
    Maria Mellinas-Gomez
    Victoria J. Spanswick
    Solange R. Paredes-Moscosso
    Matthew Robson
    R. Barbara Pedley
    David E. Thurston
    Stephen J. Baines
    Anneliese Stell
    John A. Hartley
    BMC Veterinary Research, 11
  • [23] BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models
    Ambati, Srikanth R.
    Shieh, Jae-Hung
    Pera, Benet
    Lopes, Eloisi Caldas
    Chaudhry, Anisha
    Wong, Elissa W. P.
    Saxena, Ashish
    Su, Tsann-Long
    Moore, Malcolm A. S.
    ONCOTARGET, 2016, 7 (28) : 43062 - 43075
  • [24] Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
    Mellinas-Gomez, Maria
    Spanswick, Victoria J.
    Paredes-Moscosso, Solange R.
    Robson, Matthew
    Pedley, R. Barbara
    Thurston, David E.
    Baines, Stephen J.
    Stell, Anneliese
    Hartley, John A.
    BMC VETERINARY RESEARCH, 2015, 11
  • [25] SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.: Part 1:: Cellular pharmacology, in vitro and initial in vivo antitumor activity
    Hartley, JA
    Spanswick, VJ
    Brooks, N
    Clingen, PH
    McHugh, PJ
    Hochhauser, D
    Pedley, RB
    Kelland, LR
    Alley, MC
    Schultz, R
    Hollingshead, MG
    Schweikart, KM
    Tomaszewski, JE
    Sausville, EA
    Gregson, SJ
    Howard, PW
    Thurston, DE
    CANCER RESEARCH, 2004, 64 (18) : 6693 - 6699
  • [26] SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 2: Efficacy evaluations
    Alley, MC
    Hollingshead, MG
    Pacula-Cox, CM
    Wand, WR
    Hartley, JA
    Howard, PW
    Gregson, SJ
    Thurston, DE
    Sausville, EA
    CANCER RESEARCH, 2004, 64 (18) : 6700 - 6706
  • [27] DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057
    Hartley, John A.
    Hamaguchi, Anzu
    Suggitt, Marie
    Gregson, Stephen J.
    Thurston, David E.
    Howard, Philip W.
    INVESTIGATIONAL NEW DRUGS, 2012, 30 (03) : 950 - 958
  • [28] DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057
    John A. Hartley
    Anzu Hamaguchi
    Marie Suggitt
    Stephen J. Gregson
    David E. Thurston
    Philip W. Howard
    Investigational New Drugs, 2012, 30 : 950 - 958
  • [29] SJG-136 (NSC 694501), A UNIQUE DNA MINOR GROOVE INTERSTRAND CROSS-LINKING AGENT SHOWS SIGNIFICANT ACTIVITY AND DRUG COMBINABILITY AGAINST AGGRESSIVE TYPES OF PEDIATRIC LEUKEMIA
    Narendran, Aru
    Jayanthan, Aarthi
    Singh, Anjali
    Incoronato, Andrea
    Desai, Sunil
    Whitlock, James
    PEDIATRIC BLOOD & CANCER, 2010, 54 (06) : 814 - 814
  • [30] STRUCTURE ACTIVITY RELATIONS OF (2-CHLOROETHYL)NITROSOUREAS .2. KINETIC EVIDENCE OF A NOVEL MECHANISM FOR THE CYTOTOXICALLY IMPORTANT DNA CROSS-LINKING REACTIONS OF (2-CHLOROETHYL)NITROSOUREAS
    BUCKLEY, N
    BRENT, TP
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (22) : 7520 - 7529
1234