Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3

被引：0
|
作者：
Ou, Wenbin [1 ]
Chen, Weicai [1 ]
Zhu, Jiaqing [1 ]
Eilers, Grant [2 ]
Li, Xuhui [3 ]
Yang, Peipei [1 ]
Li, Hailong [3 ]
Meng, Fanguo [3 ]
Fletcher, Jonathan [2 ]
机构：
[1] Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Tsinghua Univ, Yangtze Delta Reg Inst, Jiaxing, Peoples R China
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-2707
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2707
引用
收藏
页数：1
相关论文
共 50 条
  • [21] MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2
    L Gu
    N Zhu
    H W Findley
    M Zhou
    [J]. Leukemia, 2008, 22 : 730 - 739
  • [22] A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
    Valentine, Jane M.
    Kumar, Sonia
    Moumen, Abdeladim
    [J]. BMC CANCER, 2011, 11
  • [23] Functional Analysis of the p53 Pathway in Neuroblastoma Cells Using the Small-Molecule MDM2 Antagonist Nutlin-3
    Van Maerken, Tom
    Rihani, Ali
    Dreidax, Daniel
    De Clercq, Sarah
    Yigit, Nurten
    Marine, Jean-Christophe
    Westermann, Frank
    De Paepe, Anne
    Vandesompele, Jo
    Speleman, Frank
    [J]. MOLECULAR CANCER THERAPEUTICS, 2011, 10 (06) : 983 - 993
  • [24] MDM2 Antagonist Nutlin-3 Stimulates Global DNA Hydroxymethylation by Enhancing p53-TET1 Signaling Axis
    Wu, Danni
    Li, Yao
    Li, Cuiping
    Zhong, Shangwei
    Liu, Baodong
    Hang, Haiying
    Wang, Hailin
    [J]. ACS CHEMICAL BIOLOGY, 2023, : 2240 - 2248
  • [25] Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
    Muller, Christoph R.
    Paulsen, Erik B.
    Noordhuis, Paul
    Pedeutour, Florence
    Soeter, Gunnar
    Myklebost, Ola
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (01) : 199 - 205
  • [26] Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3 - A small molecule antagonist of MDM2
    Wang, Zhenyu
    Jonca, Malgorzata
    Lambros, Ted
    Ferguson, Stephen
    Goodnow, Robert
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 45 (05) : 720 - 729
  • [27] Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment
    Yee-Lin, Voon
    Pooi-Fong, Wong
    Soo-Beng, Alan Khoo
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2018, 18 (02) : 173 - 183
  • [28] Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism
    Polanski, Radoslaw
    Noon, Aidan P.
    Blaydes, Jeremy
    Phillips, Anna
    Rubbi, Carlos P.
    Parsons, Keith
    Vlatkovic, Nikolina
    Boyd, Mark T.
    [J]. CANCER LETTERS, 2014, 353 (02) : 211 - 219
  • [29] p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3
    Chappell, William H.
    Lehmann, Brian D.
    Terrian, David M.
    Abrams, Stephen L.
    Steelman, Linda S.
    McCubrey, James A.
    [J]. CELL CYCLE, 2012, 11 (24) : 4579 - 4588
  • [30] Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
    Ludwig, Michael P.
    Galbraith, Matthew D.
    Eduthan, Neetha Paul
    Hill, Amanda A.
    Clay, Michael R.
    Tellez, Cristiam Moreno
    Wilky, Breelyn A.
    Elias, Anthony
    Espinosa, Joaquin M.
    Sullivan, Kelly D.
    [J]. CANCER RESEARCH, 2023, 83 (15) : 2543 - 2556
12345