Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3

被引：0
|
作者：
Ou, Wenbin [1 ]
Chen, Weicai [1 ]
Zhu, Jiaqing [1 ]
Eilers, Grant [2 ]
Li, Xuhui [3 ]
Yang, Peipei [1 ]
Li, Hailong [3 ]
Meng, Fanguo [3 ]
Fletcher, Jonathan [2 ]
机构：
[1] Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Tsinghua Univ, Yangtze Delta Reg Inst, Jiaxing, Peoples R China
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-2707
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2707
引用
收藏
页数：1
相关论文
共 50 条
  • [11] Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells
    Endo, Shinji
    Yamato, Kenji
    Hirai, Sachiko
    Moriwaki, Toshikazu
    Fukuda, Kuniaki
    Suzuki, Hideo
    Abei, Masato
    Nakagawa, Ichiro
    Hyodo, Ichinosuke
    [J]. CANCER SCIENCE, 2011, 102 (03) : 605 - 613
  • [12] MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition
    Schneider, Lina S.
    Ulrich, Melanie
    Lehr, Thorsten
    Menche, Dirk
    Mueller, Rolf
    von Schwarzenberg, Karin
    [J]. MOLECULAR ONCOLOGY, 2016, 10 (07) : 1054 - 1062
  • [13] Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3
    Huang, Baoying
    Vassilev, Lyubomir T.
    [J]. AGING-US, 2009, 1 (10): : 845 - 854
  • [14] Activation of the p53 pathway by the MDM2 antagonist nutlin-3 downregulates the DNA repair protein hABH2 and sensitizes glioma cells to chemotherapy
    Johannessen, Tor-Christian A.
    Prestegarden, Lars
    Grudic, Amra
    Tysnes, Bent B.
    Bjerkvig, Rolf
    [J]. CANCER RESEARCH, 2011, 71
  • [15] A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
    Jane M Valentine
    Sonia Kumar
    Abdeladim Moumen
    [J]. BMC Cancer, 11
  • [16] The MDM2 antagonist nutlin-3 is lethal to mantle cell lymphoma with wild type p53
    Tabe, Yoko
    Szbasigari, Denise
    Rudelius, Martina
    Pittaluga, Stefania
    Raffel, Mark
    [J]. BLOOD, 2007, 110 (11) : 415A - 415A
  • [17] Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53
    He, Tianli
    Guo, Jiayou
    Song, Hongmei
    Zhu, Hongcheng
    Di, Xiaoke
    Min, Hua
    Wang, Yuandong
    Chen, Guangzong
    Dai, Wangshu
    Ma, Jianhua
    Sun, Xinchen
    Ma, Jianxin
    [J]. PATHOLOGY & ONCOLOGY RESEARCH, 2018, 24 (01) : 75 - 81
  • [18] The MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2
    Gu, Lubing
    Zhu, Ningxi
    Findley, Harry W.
    Zhou, Muxiang
    [J]. BLOOD, 2007, 110 (11) : 137B - 137B
  • [19] On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein
    ElSawy, Karim M.
    Verma, Chandra S.
    Lane, David P.
    Caves, Leo S. D.
    [J]. CELL CYCLE, 2013, 12 (24) : 3727 - 3735
  • [20] MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2
    L Gu
    N Zhu
    H W Findley
    M Zhou
    [J]. Leukemia, 2008, 22 : 730 - 739
12345