Platelets as Potential Link Between Diabetes and Alzheimer's Disease

被引：10
|
作者：
Randriamboavonjy, Voahanginirina [1 ]
Sopova, Kateryna [2 ]
Stellos, Konstantinos [2 ,3 ]
Laske, Christoph [4 ,5 ,6 ]
机构：
[1] Goethe Univ Frankfurt, Inst Vasc Signalling, Ctr Mol Med, D-60590 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Ctr Internal Med 3, Dept Cardiol, D-60596 Frankfurt, Germany
[3] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Vasc Inflammat Grp, D-60596 Frankfurt, Germany
[4] Univ Tubingen, Sect Dementia Res, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany
[5] Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany
[6] German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
来源：
CURRENT ALZHEIMER RESEARCH | 2014年 / 11卷 / 09期
关键词：
Alzheimer's disease; diabetes; platelets; vascular dementia; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; VASCULAR RISK-FACTORS; GLUCAGON-LIKE PEPTIDE-1; COATED-PLATELETS; INSULIN-RESISTANCE; MURINE MODEL; FACTOR-I; CALPAIN; BETA;
D O I：
10.2174/156720501109141013115258
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Diabetes is a well-known risk factor for Alzheimer's disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
引用
收藏
页码：862 / 868
页数：7
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