Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems

被引：42
|
作者：
Salas, Isabel H. [1 ,2 ]
De Strooper, Bart [1 ,2 ,3 ]
机构：
[1] VIB Ctr Brain & Dis Res, Leuven, Belgium
[2] Katholieke Univ Leuven, Dept Neurosci, Leuven, Belgium
[3] ION UCL, UK Dementia Res Inst, DRI UK, London, England
来源：
NEUROCHEMICAL RESEARCH | 2019年 / 44卷 / 06期
关键词：
Alzheimer's disease; Diabetes; Dementia; Amyloid; Insulin; Glycemia; Metabolic stress; Cognition; HIGH-FAT DIET; MILD COGNITIVE IMPAIRMENT; INSULIN-DEGRADING ENZYME; TRANSGENIC MOUSE MODEL; BRAIN INSULIN; RISK-FACTORS; INTRANASAL INSULIN; VASCULAR DEMENTIA; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
D O I：
10.1007/s11064-018-2690-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Type 2 diabetes mellitus is associated with an increased risk to develop Alzheimer disease, however, the underlying mechanisms for this association are still unclear. In this review we will provide a critical overview of the major findings coming from clinical studies and animal models.
引用
收藏
页码：1271 / 1278
页数：8
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