Platelets as Potential Link Between Diabetes and Alzheimer's Disease

被引：10

作者：

Randriamboavonjy, Voahanginirina ^{[1
]}

Sopova, Kateryna ^{[2
]}

Stellos, Konstantinos ^{[2
,3
]}

Laske, Christoph ^{[4
,5
,6
]}

机构：

[1] Goethe Univ Frankfurt, Inst Vasc Signalling, Ctr Mol Med, D-60590 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Ctr Internal Med 3, Dept Cardiol, D-60596 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Vasc Inflammat Grp, D-60596 Frankfurt, Germany

[4] Univ Tubingen, Sect Dementia Res, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[5] Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany

[6] German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany

来源：

CURRENT ALZHEIMER RESEARCH | 2014年 / 11卷 / 09期

关键词：

Alzheimer's disease; diabetes; platelets; vascular dementia; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; VASCULAR RISK-FACTORS; GLUCAGON-LIKE PEPTIDE-1; COATED-PLATELETS; INSULIN-RESISTANCE; MURINE MODEL; FACTOR-I; CALPAIN; BETA;

D O I：

10.2174/156720501109141013115258

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diabetes is a well-known risk factor for Alzheimer's disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.

引用

页码：862 / 868

页数：7

共 50 条

[1] Erythrocytes as Potential Link between Diabetes and Alzheimer's Disease
Carelli-Alinovi, Cristiana
Misiti, Francesco
[J]. FRONTIERS IN AGING NEUROSCIENCE, 2017, 9
[2] Plasma Clusterin as a Potential Link Between Diabetes and Alzheimer Disease
Ha, Junghee
Moon, Min Kyong
Kim, Hyunjeong
Park, Minsun
Cho, So Yeon
Lee, Jimin
Lee, Jun-Young
Kim, Eosu
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (09): : 3058 - 3068
[3] Amylin as a potential link between type 2 diabetes and alzheimer disease
Martinez-Valbuena, Ivan
Valenti-Azcarate, Rafael
Amat-Villegas, Irene
Riverol, Mario
Marcilla, Irene
de Andrea, Carlos E.
Antonio Sanchez-Arias, Juan
del Mar Carmona-Abellan, Maria
Marti, Gloria
Erro, Maria-Elena
Martinez-Vila, Eduardo
Tunon, Maria-Teresa
Luquin, Maria-Rosario
[J]. ANNALS OF NEUROLOGY, 2019, 86 (04) : 539 - 551
[4] Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease
Despa, Florin
Goldstein, Larry B.
Biessels, Geert Jan
[J]. ANNALS OF NEUROLOGY, 2020, 87 (03) : 486 - 486
[5] Homocysteine: A Potential Molecular Link between Alzheimer's Disease and Type 2 Diabetes Mellitus
Vollmer, Cyndel
Mcnay, Ewan
[J]. DIABETES, 2012, 61 : A428 - A428
[6] Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease
Kulas, Joshua A.
Weigel, Thaddeus K.
Ferris, Heather A.
[J]. DRUG DEVELOPMENT RESEARCH, 2020, 81 (02) : 194 - 205
[7] Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease
Jash, Kavya
Gondaliya, Piyush
Kirave, Prathibha
Kulkarni, Bhagyashri
Sunkaria, Aditya
Kalia, Kiran
[J]. DRUG DEVELOPMENT RESEARCH, 2020, 81 (02) : 144 - 164
[8] TLR4 is a link between diabetes and Alzheimer's disease
Huang, Nan-Qu
Jin, Hai
Zhou, Shao-yu
Shi, Jing-shan
Jin, Feng
[J]. BEHAVIOURAL BRAIN RESEARCH, 2017, 316 : 234 - 244
[9] Insulin resistance as the molecular link between diabetes and Alzheimer's disease
Abdalla, Mona Mohamed Ibrahim
[J]. WORLD JOURNAL OF DIABETES, 2024, 15 (07)
[10] Brain mitochondrial dysfunction as a link between Alzheimer's!disease and diabetes
Moreira, Paula I.
Santos, Maria S.
Selca, Raquel
Oliveira, Catarina R.
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 257 (1-2) : 206 - 214

← 1 2 3 4 5 →