Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody

被引：143
|
作者：
van der Ent, Cornelis K.
Hoekstra, Hans
Rijkers, Ger T.
机构：
[1] Univ Utrecht, Ctr Med, Dept Pediat Resp Dis, NL-3508 AB Utrecht, Netherlands
[2] Hieronyms Bosch Hosp, Dept Pediat, sHertogenbosch, Netherlands
[3] Univ Utrecht, Ctr Med, Dept Pediat Immunol, Utrecht, Netherlands
来源：
THORAX | 2007年 / 62卷 / 03期
关键词：
D O I：
10.1136/thx.2004.035519
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Allergic bronchopulmonary aspergillosis (ABPA) can cause severe worsening of the respiratory condition in patients with cystic fibrosis. Treatment can result in steroid dependency and serious adverse events. A dramatic and rapid improvement of respiratory symptoms and lung function after a single dose of anti-IgE antibody (omalizumab) in a 12-year-old girl with cystic fibrosis and ABPA is described. This is the first report of this experimental treatment. It suggests an important role for IgE in the pathogenesis of ABPA and offers new therapeutic possibilities.
引用
收藏
页码：276 / 277
页数：2
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