Design of peptides derived from anti-IgE antibody for allergic treatment

被引：7
|
作者：
Takahashi, M
Ohgitani, Y
Ueno, A
Mihara, H
机构：
[1] Tokyo Inst Technol, Fac Biosci & Biotechnol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 2268501, Japan
[2] Japan Sci & Technol Corp, PRESTO, Form & Funct, Kyoto, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期
关键词：
D O I：
10.1016/S0960-894X(99)00354-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have designed and synthesized peptides derived from an anti-IgE antibody which has a potential for the treatment of allergy. It was indicated that conformational restriction of peptide via an intramolecular disulfide bond improved the binding affinity for IgE and that the peptide might have an ability to inhibit the IgE-receptor interaction. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2185 / 2188
页数：4
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