NFATc1 in Inflammatory and Musculoskeletal Conditions

被引：16
|
作者：
Aliprantis, Antonios O. [1 ,2 ]
Glimcher, Laurie H. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS II | 2010年 / 658卷
关键词：
NFATc1; Osteoclast; Hair follicle; OSTEOCLAST-ASSOCIATED RECEPTOR; T-CELLS C1; NUCLEAR-FACTOR; GENE-EXPRESSION; BONE-RESORPTION; GIANT-CELL; ACTIVATION; RANKL; DIFFERENTIATION; IMMUNE;
D O I：
10.1007/978-1-4419-1050-9_8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contributed to our understanding of this transcription factor in inflammatory and musculoskeletal conditions and their treatment.
引用
收藏
页码：69 / 75
页数：7
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