NFATc1 in Inflammatory and Musculoskeletal Conditions

被引：16
|
作者：
Aliprantis, Antonios O. [1 ,2 ]
Glimcher, Laurie H. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS II | 2010年 / 658卷
关键词：
NFATc1; Osteoclast; Hair follicle; OSTEOCLAST-ASSOCIATED RECEPTOR; T-CELLS C1; NUCLEAR-FACTOR; GENE-EXPRESSION; BONE-RESORPTION; GIANT-CELL; ACTIVATION; RANKL; DIFFERENTIATION; IMMUNE;
D O I：
10.1007/978-1-4419-1050-9_8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contributed to our understanding of this transcription factor in inflammatory and musculoskeletal conditions and their treatment.
引用
收藏
页码：69 / 75
页数：7
相关论文
共 50 条
  • [31] Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity
    Dietz, L.
    Qureischi, M.
    Xiao, Y.
    Vallabhapurapu, S. D.
    Klein-Hessling, S.
    Klein, M.
    Konig, A.
    Serfling, E.
    Mottok, A.
    Bopp, T.
    Rosenwald, A.
    Buttmann, M.
    Berberich, I
    Beilhack, A.
    Berberich-Siebelt, F.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 685 - 685
  • [32] The impact of a LysM-specific NFATc1 knockout on neutrophil antifungal defense and myelopoiesis in NFATc1 LysM mice infected with Aspergillus fumigatus
    Teschner, D.
    Michel, C.
    Pruefer, S.
    Theobald, M.
    Schild, H.
    Radsak, M.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 9 - 9
  • [33] NFATc1/αA: The other Face of NFAT Factors in Lymphocytes
    Serfling, Edgar
    Avots, Andris
    Klein-Hessling, Stefan
    Rudolf, Ronald
    Vaeth, Martin
    Berberich-Siebelt, Friederike
    CELL COMMUNICATION AND SIGNALING, 2012, 10
  • [34] NFATc1/αA: The other Face of NFAT Factors in Lymphocytes
    Edgar Serfling
    Andris Avots
    Stefan Klein-Hessling
    Ronald Rudolf
    Martin Vaeth
    Friederike Berberich-Siebelt
    Cell Communication and Signaling, 10
  • [35] Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis
    Grossinger, Eva M.
    Kang, Mincheol
    Bouchareychas, Laura
    Sarin, Ritu
    Haudenschild, Dominik R.
    Borodinsky, Laura N.
    Adamopoulos, Iannis E.
    JOURNAL OF IMMUNOLOGY, 2018, 200 (02): : 749 - 757
  • [36] DYRK1A activates NFATC1 to increase glioblastoma migration
    Liu, Heng
    Sun, Qian
    Chen, Shuai
    Chen, Long
    Jia, Wenming
    Zhao, Juan
    Sun, Xiulian
    CANCER MEDICINE, 2021, 10 (18): : 6416 - 6427
  • [37] NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors
    Langworthy, Melissa
    Zhou, Bin
    de Caestecker, Mark
    Moeckel, Gilbert
    Baldwin, H. Scott
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (02): : 311 - 321
  • [38] TNF-α synthesis is differentially regulated by NFATc1 and NFATc2 in T cells
    Kaminuma, Osamu
    Kitamura, Fujiko
    Kitamura, Noriko
    Miyatake, Shoichiro
    Hiroi, Takachika
    FASEB JOURNAL, 2008, 22
  • [39] Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
    Song, Min-Kyoung
    Park, Cheolkyu
    Lee, Yong Deok
    Kim, Haemin
    Kim, Min Kyung
    Kwon, Jun-Oh
    Koo, Ja Hyun
    Joo, Min Sung
    Kim, Sang Geon
    Kim, Hong-Hee
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (02) : 849 - 860
  • [40] VEGF and RANKL Regulation of NFATc1 in Heart Valve Development
    Combs, Michelle D.
    Yutzey, Katherine E.
    CIRCULATION RESEARCH, 2009, 105 (06) : 565 - U147
12345