Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

被引:16
|
作者
Lee, Seoung Rak [1 ]
Moon, Eunjung [2 ]
Kim, Ki Hyun [1 ]
机构
[1] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea
[2] Charmzone Co LTD, Charmzone R&D Ctr, Seoul 135851, South Korea
关键词
Pharbitis nil; Neolignan; Monoterpene glycoside; Anti-inflammation; Cytotoxicity; CISPLATIN-INDUCED NEPHROTOXICITY; EUONYMUS-ALATUS TWIGS; CANCER CELLS; STEM BARK; CONSTITUENTS; IDENTIFICATION; ANTIOXIDANT; FLAVONOIDS; MECHANISM; APOPTOSIS;
D O I
10.1016/j.phytol.2017.04.019
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R, 8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z, 7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-beta-D-glucopyranoside (2), together with a known compound, ethyl alpha-L-arabinofuranoside (3). The chemical structures of these compounds were unambiguously determined using physical data, HR-ESI-MS and spectroscopic evidence, including 1D and 2D NMR experiments. The anti-inflammatory activities of the isolates were evaluated by estimating the inhibition of nitric oxide (NO) production. Compounds 1 and 2 reduced NO levels in lipopolysaccharide (LPS)-stimulated murine microglial BV-2 cells. In addition, compound 2 showed weak cytotoxicity against the HCT-15 cell line with an IC50 value of 28.6 mu M.
引用
收藏
页码:98 / 101
页数:4
相关论文
共 50 条
  • [31] A novel neolignan glycoside from Aquilaria sinensis
    Wu, Yi
    Liu, Chang
    Li, Hui-Fen
    Sun, Jian-Bo
    Li, You-Ying
    Gu, Wei
    Wang, De-Yun
    Liu, Jia-Guo
    Hu, Yuan-Liang
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2014, 55 : 41 - 45
  • [32] A new neolignan glycoside from Pedicularis armata
    Yuan, CS
    Zhang, ZX
    Gao, X
    Jia, ZR
    CHINESE CHEMICAL LETTERS, 2005, 16 (06) : 781 - 782
  • [33] Inheritance of pubescence in Pharbitis nil
    Imai, Yoshitaka
    BOTANICAL GAZETTE, 1926, 81 (1-4): : 103 - 107
  • [34] Metabolite Profile, Ruminal Methane Reduction, and Microbiome Modulating Potential of Seeds of Pharbitis nil
    Bharanidharan, Rajaraman
    Thirugnanasambantham, Krishnaraj
    Ibidhi, Ridha
    Baik, Myunggi
    Kim, Tae Hoon
    Lee, Yookyung
    Kim, Kyoung Hoon
    FRONTIERS IN MICROBIOLOGY, 2022, 13
  • [35] A New Neolignan Glycoside from Vetiveria zizanioides Roots
    Matsuo, Yukiko
    Ohba, Chika
    Maeda, Saori
    Fukaya, Haruhiko
    Mimaki, Yoshihiro
    NATURAL PRODUCT COMMUNICATIONS, 2016, 11 (07) : 983 - 985
  • [36] A New Neolignan Glycoside from the Roots of Acanthopanax brachypus
    Hu, Hao-Bin
    Zheng, Xu-Dong
    Hu, Huai-Sheng
    Li, Yan
    ACTA CHIMICA SLOVENICA, 2009, 56 (02) : 470 - 474
  • [37] A NEW NEOLIGNAN GLYCOSIDE FROM SAMBUCUS-RACEMOSA
    FRANZ, C
    GROSS, GA
    ANKLIN, C
    STICHER, O
    PLANTA MEDICA, 1986, (06) : 527 - 529
  • [38] A new neolignan glycoside from the leaves of Acer truncatum
    Dong, Lang-Ping
    Ni, Wei
    Dong, Jin-Yang
    Li, Jun-Zhu
    Chen, Chang-Xiang
    Liu, Hai-Yang
    MOLECULES, 2006, 11 (12) : 1009 - 1014
  • [39] GIBBERELLINS IN IMMATURE SEEDS OF PHARBITIS-NIL .3. ISOLATION AND STRUCTURES OF GIBBERELLIN GLUCOSIDES
    YOKOTA, T
    MUROFUSH.N
    TAKAHASH.N
    TAMURA, S
    AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1971, 35 (04): : 580 - &
  • [40] New neolignan glycoside from Pteris multifida poir
    Zheng, Xu-dong
    Hu, Hao-bin
    Hu, Huai-sheng
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2008, 29 (06): : 1250 - 1252