Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

被引:16
|
作者
Lee, Seoung Rak [1 ]
Moon, Eunjung [2 ]
Kim, Ki Hyun [1 ]
机构
[1] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea
[2] Charmzone Co LTD, Charmzone R&D Ctr, Seoul 135851, South Korea
关键词
Pharbitis nil; Neolignan; Monoterpene glycoside; Anti-inflammation; Cytotoxicity; CISPLATIN-INDUCED NEPHROTOXICITY; EUONYMUS-ALATUS TWIGS; CANCER CELLS; STEM BARK; CONSTITUENTS; IDENTIFICATION; ANTIOXIDANT; FLAVONOIDS; MECHANISM; APOPTOSIS;
D O I
10.1016/j.phytol.2017.04.019
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R, 8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z, 7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-beta-D-glucopyranoside (2), together with a known compound, ethyl alpha-L-arabinofuranoside (3). The chemical structures of these compounds were unambiguously determined using physical data, HR-ESI-MS and spectroscopic evidence, including 1D and 2D NMR experiments. The anti-inflammatory activities of the isolates were evaluated by estimating the inhibition of nitric oxide (NO) production. Compounds 1 and 2 reduced NO levels in lipopolysaccharide (LPS)-stimulated murine microglial BV-2 cells. In addition, compound 2 showed weak cytotoxicity against the HCT-15 cell line with an IC50 value of 28.6 mu M.
引用
收藏
页码:98 / 101
页数:4
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