Treatment of Class IV Lupus Nephritis with Mycophenolate Mofetil Monotherapy

被引：1

作者：

Nawata, Takashi ^{[1
]}

Kubo, Makoto ^{[1
]}

Fujii, Shohei ^{[1
]}

Shiragami, Kosaku ^{[1
]}

Ikegami, Tadayoshi ^{[1
]}

Kobayashi, Shigeki ^{[1
]}

Hisano, Satoshi ^{[2
]}

Yano, Masafumi ^{[1
]}

机构：

[1] Yamaguchi Univ, Dept Med & Clin Sci, Div Cardiol & Clin Immunol, Grad Sch Med, Yamaguchi, Japan

[2] Fukuoka Univ, Dept Pathol, Fac Med, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 14期

基金：

日本学术振兴会;

关键词：

lupus nephritis; monotherapy; mycophenolate mofetil; steroid-free; HEART-FAILURE; CYCLOPHOSPHAMIDE; MECHANISMS; GLUCOCORTICOIDS; ERYTHEMATOSUS; INDUCTION;

D O I：

10.2169/internalmedicine.0304-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lupus nephritis (LN) occurs in up to 60% of systemic lupus erythematosus patients. Combination therapy involving a corticosteroid and cyclophosphamide or mycophenolate mofetil (MMF) has been a standard therapy for LN. However, clinicians generally prefer to minimize steroid use in LN treatment. We herein report the case of a Japanese man with LN whose severe chronic heart failure prevented us from using steroid therapy. Instead, his LN was successfully treated with MMF monotherapy. Based on our experience with this case, we suggest that MMF monotherapy may represent a feasible LN treatment option in patients who cannot tolerate steroid therapy.

引用

页码：2067 / 2070

页数：4

共 50 条

[41] Treatment with mycophenolate mofetil in vasculitis and lupus nephritis - One centre experience
Kazderova, Marketa
Rysava, Romana
Jancova, Eva
Merta, Miroslav
Tesar, Vladimir
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 : 75 - 75
[42] Mycophenolate Mofetil for Induction Treatment of Lupus Nephritis: A Systematic Review and Metaanalysis
Touma, Zahi
Gladman, Dafna D.
Urowitz, Murray B.
Beyene, Joseph
Uleryk, Elizabeth M.
Shah, Prakesh S.
[J]. JOURNAL OF RHEUMATOLOGY, 2011, 38 (01) : 69 - 78
[43] Can mycophenolate mofetil substitute cyclophosphamide treatment of pediatric lupus nephritis?
Paredes, Ana
[J]. PEDIATRIC NEPHROLOGY, 2007, 22 (08) : 1077 - 1082
[44] Successful Treatment with Mycophenolate Mofetil and Tacrolimus in Juvenile Severe Lupus Nephritis
Kise, Tomoo
Yoshimura, Hiroshi
Fukuyama, Shigeru
Uehara, Masatsugu
[J]. CASE REPORTS IN PEDIATRICS, 2015, 2015
[45] Rituximab and mycophenolate mofetil: Induction treatment and maintenance of severe lupus nephritis
Guzman, R. A.
Roa, G. M.
Garcia, O.
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 306 - 306
[46] Can mycophenolate mofetil substitute cyclophosphamide treatment of pediatric lupus nephritis?
Ana Paredes
[J]. Pediatric Nephrology, 2007, 22 : 1077 - 1082
[47] MYCOPHENOLATE MOFETIL TREATMENT FOR RESISTANT LUPUS NEPHRITIS: A SINGLE CENTER EXPERIENCE
Velioglu, Arzu
Guler, Derya
Nalcaci, Serdar
Birdal, Gurdal
Arikan, Hakki
Koc, Mehmet
Direskeneli, Haner
Tuglular, Serhan
Ozener, Cetin
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 183 - 184
[48] Mycophenolate mofetil for treatment of refractory lupus nephritis: four pilot cases
Wallman, L
Stewart, G
Chapman, J
O'Connell, P
Fulcher, D
[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 2000, 30 (06): : 712 - 715
[49] The treatment of severe lupus nephritis with mycophenolate mofetil—a meta-analysis
[J]. Nature Clinical Practice Nephrology, 2007, 3 (10): : 525 - 525
[50] Cyclophosphamide versus mycophenolate mofetil for initial treatment of lupus nephritis Reply
Radhakrishnan, Jai
Cattran, Daniel
[J]. KIDNEY INTERNATIONAL, 2013, 83 (05) : 969 - 969

← 1 2 3 4 5 →